Given the lack of a comprehensive, multi-faceted overview of the ketogenic diet (KD) in terms of health issues, we’ve compiled the evidence on the use of the ketogenic diet in terms of its effects on the microbiome, epigenome, diabetes, weight loss, cardiovascular health, and cancer. The KD diet could potentially increase the genetic diversity of the microbiome and increase the ratio of Bacteroidetes to Firmicutes. The epigenome could be positively affected by KD as it produces a signaling molecule known as β-hydroxybutyrate (BHB). KD has helped patients with diabetes lower their HbA1c levels and reduce insulin requirements.
There is evidence that a KD can help with weight loss, visceral obesity, and appetite control. The evidence also suggests that a high-fat diet improves lipid profiles by lowering low-density lipoprotein (LDL), increasing high-density lipoprotein (HDL), and lowering triglycerides (TG). Because of the Warburg effect, KD is used as an adjuvant treatment to starve cancer cells, making them more susceptible to chemotherapy and radiation. The potential positive effects of KD on each of these areas require further analyses, improved trials, and well-designed randomized controlled trials to further illuminate the therapeutic options of this dietary intervention.
Thankfully, plenty of research suggests that switching your diet to a low-carb or ketogenic diet can help people lower their insulin to healthy levels and reverse insulin resistance. The keto diet allows many people to eat the high-fat foods they like, such as red meat, fatty fish, nuts, cheese, and butter, and lose weight at the same time. Any ketogenic diet or any other diet can only be effective if you commit to it for your condition and lifestyle. The researchers compared the effects of a low-carb diet with the effects of a combination of a low-fat diet and orlistat (a weight loss and blood pressure medication) on blood pressure.
Some people also experience dehydration while on the keto diet because they remove glycogen, which contains water, from their bloodstream. At least in the short term, studies show that keto diets produce amazing and rapid weight loss results. The keto diet is being studied to relieve symptoms in patients with progressive neurological disorders such as Parkinson’s disease, but scientific research has not confirmed any benefits for these populations. The focus of this study was on determining whether diet had a negative effect on lipid profiles, as this is a current concern for many doctors and may limit their decision whether to suggest the KD diet to their cancer patients.
The effects of the prescribed low-fat diet compared to high-fat diets on cardiovascular lipid levels are gradually becoming apparent. In this study, researchers compared the effects of a low-carb diet and three other diets on blood pressure and other measures of cardiovascular fitness in women. To understand why you could burn fat better on a keto diet or in ketosis, think of your body as a car. Some researchers swear it’s the best diet for most people, while others think it’s just another fad diet.
It could also be stated that fecal microbiota transplants could be necessary to completely alter and alter the microbiome at the start of a new diet, which could then be further modified and improved through nutrition. It is important to clarify that a low-carb diet typically refers to a diet with an intake of 50 to 150 g of carbohydrates per day. It therefore seems reasonable to hypothesize that a diet could have profound effects on reducing the risk of cancer, particularly when it is known that this diet lowers body weight, lowers insulin levels and combats the metabolic deficiencies of cancer cells.